Alendronate, or Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget’s disease of bone. It is taken by mouth.Use is often recommended together with vitamin D, calcium supplementation, and lifestyle changes.
Common side effects include constipation, abdominal pain, nausea, and acid reflux. Serious side effects may include esophageal problems, osteonecrosis of the jaw, and femur fractures. Use is not recommended during pregnancy or in those with poor kidney function. Alendronic acid works by decreasing the activity of cells that breakdown bone.
Alendronate was first described in 1978 and approved for medical use in the United States in 1995. It is available as a generic medication. In the United Kingdom, a month of medication costs the NHS about 0.41 pounds as of 2019. In the United States, the wholesale cost is about US$1.16 per month.In 2016, it was the 73rd most prescribed medication in the United States, with more than 10 million prescriptions.
What is osteoporosis? Osteoporosis occurs when the body loses too much bone or does not produce enough of it. Bones become less dense, which makes them weaker and more likely to break. Osteoporosis is very common after the age of 50: approximately one in two women and one in four men over 50 years old […]